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Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing
Mind over Matter: With its backstage access through the blood-brain barrier, Acetyl L-Carnitine can hobnob with neurotransmitter systems like acetylcholine, providing nourishment where it matters
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Debeljak Martacic et al., 2016
Meth Enzymol 113: 484490
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