Jafari-Vayghan, H., Varshosaz, P., Hajizadeh-Sharafabad, F., Razmi, H
The increased demand for GLP1 drugs outpaced the supply
This is primarily driven by the GLP-1 receptor-mediated slowing of gastric emptying and the central appetite signaling effects that retatrutide shares with semaglutide and tirzepatide
But researchers are now discovering they might also protect the brain by: Reducing inflammation in the brain Improving blood vessel function Lowering oxidative stress Possibly slowing down the brain changes seen in Alzheimers disease In animal studies, these medications have been shown to protect neurons, the cells responsible for memory and movement
2 GLP-1 is an incretin hormone produced by intestinal L cells that is responsible for up to 70% of insulin secretion in response to nutrient intake