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Avoid use during pregnancy or breastfeeding

Small shifts in storage conditions, thaw-refreeze practices, or internal standard selection can accumulate into significant variability, making it difficult to interpret subtle but biologically meaningful differences in endpoints such as glucose tolerance, body-composition proxies, or signaling-pathway activation

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Patients who want to stay informed about changes should follow updates from the FDA, the National Community Pharmacists Association, and their state pharmacy boards

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