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Researchers should also recognize that the combinations per-unit efficiency means that a well-designed combination protocol frequently achieves a larger research signal at a lower total compound cost than a single-compound protocol producing the same effect, which is part of why the combination dosing approach dominates the published GH-axis research literature

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Powder More affordable and can be mixed with beverages, but dosing accuracy may be challenging

GLP-1s were considered a second-line agent

While all four of these trials did enroll patients with established ASCVD, the SELECT trial showed benefit for patients with no history of T2DM