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Avoid use if you have severe kidney disease or are on dialysis unless closely supervised by a nephrologist

2 In the SURMOUNT-1 trial, 25.9% of tirzepatide participants experienced nausea, and 4.37.1% discontinued due to adverse events (depending on dose)

The company also argues that Rejuva could be easier to tolerate, since the therapy would really only stimulate added production in response to food, as opposed to the high circulating levels of GLP-1 induced by drugs

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