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The participants who received the 7.2mg dose lost an average of nearly 21% of their body weight compared with 17.5% for those on the standard dose

Further exploration uncovered that canagliflozin had the capability to increase the expression of -H2AX, a marker of DNA damage, and activated the DNA damage response signaling pathway ATM/CHK2

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Material and Methods Chemicals and reagents Rotenone, sulforaphane, dimethyl sulfoxide (DMSO), 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA) and 2,7-dichlorofluorescein (DCF) were purchased from Sigma (St

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