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further splitting adds little High efficacy retention: Even daily microdosing maintains ~85% theoretical efficacy Long half-life advantage: Semaglutide's natural stability means less benefit from splitting vs

Gonzalez A, Hall MN, Lin SC, Hardie DG

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Results: Several studies have discussed the CV beneficial effects of GLP-1 RAs in terms of reducing blood pressure, lipid levels, body weight, risk for arrhythmias, reducing the risk of major adverse CV events, and hospital admission for heart failure