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Introduction Drug shortages of long-acting GLP-1 receptor agonists and dual GLP-1/GIP receptor agonist have emerged unexpectedly and persisted through the first quarter of 2023
Tirzepatide, meanwhile, combines the effects of both GLP-1 and GIP receptor agonists, offering dual action that may further enhance appetite suppression and metabolic benefits
Furthermore, it reduced lung abnormalities in a MERS-CoV challenge mouse model, although the immunogenicity and protective efficacy of the NTD protein were weaker than the RBD protein 128
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