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This hypothesis is somewhat weakened by mixed data for transverse aortic constriction rodent models

Animal research shows that berberine can prolong pentobarbital-induced sleeping time
Redox Signal 20 , 574588 (2014)
doi: 10.1021/jf020635c PubMed Abstract | CrossRef Full Text | Google Scholar Balfour, E

Collectively, these in vitro data provide direct mechanistic evidence that exerkine pathways can modulate cell viability, apoptosis, barrier function, ROS generation and inflammatory mediators in retinal cells relevant to DR ( Figure 3 )

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