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(2010) Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India

The oral administration of B12 (in pill form) carries significant drawbacks: Vitamin B12 is absorbed in the terminal ileum

First, it works through beta-3 adrenergic receptors, which are predominantly expressed in adipose tissue with limited expression in most other tissues

The activated lipase breaks down stored triglycerides into free fatty acids that can be released into the bloodstream and oxidized for energy

Although a Statistics Canada population survey published in 2013 found, on average, seniors had only slightly lower levels of B12 than younger adults