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A 2025 meta-analysis by South Valley University found a similar pattern when it pooled the Yale trial with 2 others

The SURMOUNT-1 trial showed tirzepatide at its highest dose produced 22.5% weight loss over 72 weeks

When looking at safety, most of the treatment-emergent adverse events (TEAEs) were mild to moderate in severity and gastrointestinal-related, according to the company

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Taking the supplement in divided doses around meals, starting with a low dose (500 mg), can help improve tolerance and support better results over time