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The mice were divided into three groups and treated with tail vein injections of either saline (Saline), scExe4 donor plasmid loaded LNP alone (Donor), or scExe4 donor plasmid loaded LNP plus Cas9 plasmid loaded LNP (Donor+Cas9)
These data are crucial for understanding how L-carnitine supplementation may influence metabolic efficiency
doi: 10.1016/S01406736(21)014434 75 Del PratoSKahnSEPavoIWeerakkodyGJYangZDoupisJet al
Ongoing monitoring typically involves monthly or quarterly check-ins during dose titration, regular assessment of weight loss progress and tolerability, periodic lab work to monitor metabolic parameters, and screening for potential complications
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Additional measures could also include intubating selected patients on these medications instead of canceling procedures, since many of these patients also have comorbidities that may necessitate aspiration precautions such as intubation
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