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It directly inhibited the stearoyl-CoA desaturase-1 (SCD1) protein to trigger ferroptosis of ovarian cancer, evidenced by the increased ROS, total iron, and Fe 2+ levels and downregulation of ferroptosis inhibitors (SLC7A11 and GPX4), thus suppressing cancer progression in the SKOV-3 xenograft model (Liu et al., 2022)
CHO-K1 cells (ATCC) were stably transfected with a human GLP-1R expression plasmid and maintained in Dulbeccos Modified Eagle Medium, 10% fetal bovine serum, 500 g/mL geneticin and 400 g/mL hygromycin B
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Mounjaro/Zepbound (tirzepatide) is a GLP1/GIP dual agonist (~2022.5% loss)
Immune Function: GSH supports immune function by modulating immune cell activity, including lymphocyte proliferation and cytokine production
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