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Based on the 3D-structure of the human TBC1D15 GAP domain in complex with human Rab7-GTP, we performed virtual ligand-based screening of a compound library at druggable sites at the TBC1D15/Rab7-GTP interface

Guo H, Ouyang Y, Yin H, Cui H, Deng H, Liu H, et al

New landmark data, presented by the manufacturer Novo Nordisk, shows Wegovy can protect against heart disease in the earliest stages, while also working to dramatically cut the risk of having a heart attack, stroke or early death in high-risk patients

These gastrointestinal side effects may lead to electrolyte imbalances, particularly low magnesium levels, which can trigger muscle spasms, including eye twitching

Skipping rehabilitation may result in healed but weak tissue prone to re-injury