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Vitamin E (-tocopherol) is a lipid-soluble antioxidant that protects biological membranes from oxidative damage and upregulates antioxidant enzymes

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Participants were randomized to receive tirzepatide at doses of 5 mg, 10 mg, or 15 mg weekly, or placebo, for 176 weeks (over three years), followed by a 17-week off-treatment period

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