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Discard if cloudy, discolored, or showing floating particles after 5 to 10 minutes of gentle mixing

Several important considerations apply: Individuals with active or severe gastrointestinal disease may experience worsening symptoms due to the gastrointestinal side effects of GLP-1 medications The slowed gastric emptying caused by these drugs could theoretically exacerbate symptoms in people with strictures or obstructive complications of Crohn's disease Weight loss associated with GLP-1 therapy may be inappropriate in patients with Crohn's disease who are already experiencing malnutrition or unintentional weight loss The interaction between GLP-1 medications and the inflammatory processes in IBD is not fully understood Clinical decision-making should involve a thorough assessment of disease activity, nutritional status, presence of complications (such as strictures or fistulas), and the primary indication for GLP-1 therapy

At 2 mg/mL, the 2.4 mg maintenance dose requires 1.2 mL, which exceeds a standard 1 mL insulin syringe

Intensive Care Med , 1999

They help you weigh the pros and cons, ensuring that GLP-1 therapy is the right fit for your specific health needs