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26 We employed PDAC cell lines, autochthonous in vivo models, and patient-derived organoids representing the full spectrum of molecular subtypes to reveal multilayered metabolic alterations in response to dual SHP2/MEK inhibition

Results at 6-8 weeks (reduced shedding) and 3-4 months (new growth)

This effect appears primarily mediated by weight loss and reduction in ectopic fat deposition in humans, though some preclinical evidence suggests potential direct effects on insulin signaling pathways

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Cabe destacar, no obstante, que el consumo de cereales integrales y legumbres, aunque sea en forma de harina, sigue siendo una opcin ms favorable que los cereales refinados y que los alimentos de origen animal en lo que factores de riesgo cardiometablico y riesgo de enfermedades crnicas se refiere