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Approval was granted by the Ethical Committee of the Animal Welfare Office of the Italian Health Ministry (Authorization No

The simultaneous timing reflects the convergence of parallel regulatory reviews, not a decision to waive individual evaluation

[80] The condition is easily treatable with abstinence or lowering of kava intake, as the skin appears to be returning to its normal state within a couple of weeks of reduced or no kava use

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However, the inhibitory effect of melanin on melanoma metastasis, if confirmed in future studies, may have potential clinical implications for melanoma diagnosis