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In fact, anakinra was associated with higher rates of acute kidney injury and significantly lower survival than the SOC.34 Although canakinumab showed histological improvement, it did not reduce mortality or change Lille or MELD scores [35]
[2] Frias JP, Deenadayalan S, Erichsen L, Knop FK, Lingvay I, Macura S, Mathieu C, Pedersen SD, Davies M
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Vascular dysfunction may impair amyloid clearance and contribute synergistically to neurodegeneration
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