glp-1 fatty liver Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression 🩺 𝐅𝐚𝐭𝐭𝐲 𝐋𝐢𝐯𝐞𝐫 𝐂𝐚𝐧 𝐁𝐞

Mosenzon O, Alguwaihes A, Arenas Leon JL, Bayram F, Darmon P, Davis T, et al

It takes approximately 4 to 5 weeks of consistent daily dosing to reach steady-state blood levels

These symptoms can vary in severity and duration, impacting patients quality of life

A phase I/II clinical trial found that the most common side effects were mild and transient (Teichman et al., 2006): Injection site reactions (redness, mild swelling) Headaches Flushing or warmth Temporary water retention Joint tightness or tingling Transient fatigue or dizziness Serious adverse events are rare when the peptide is used under medical supervision at appropriate doses

- Opportunity for new delivery formats (oral, depot injectables)