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Nrf2/ARE-dependent genes code for numerous mediators of the antioxidant response, including GCL, glutathione S-transferases (GSTs), thioredoxin, NAD(P)H quinone oxidoreductase 1 (NQO-1), and heme oxygenase 1 (HO-1) (21)

Subsequent biochemistry assays confirmed that DMF significantly increases GSH, cystathionine, and cysteine levels, along with moderately increased homocysteine levels (Fig

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As FAD is the cofactor of the ETC complex II and fatty acid oxidation critical for mitochondrial bioenergetics, a lack of fitness defect of the SLC25A32 KOs in galactose when cells depend on respiration for survival (Fig

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