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doi: 10.1007/s13311-021-01036-3 218
2022 Mar 16;14(6):1255
It travels through your stomach and liver first, which breaks down some of the medication before it even reaches your blood
doi:10.1530/raf-20-0037 Salvio G, Cutini M, Ciarloni A, Giovannini L, Perrone M, Balercia G
Meperidine (initial dose 2550 mg i.v.) has shorter half-life but puts patients are at higher risk of metabolite accumulation (neuromuscular side effects) when repeated doses accumulate
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