GLP-1 receptor agonists such as exenatide, liraglutide, semaglutide, and tirzepatide provide glucose-dependent insulin stimulation, weight reduction, and cardiovascular benefits
Glutathione boosters: cruciferous vegetables (broccoli, kale, Brussels sprouts), garlic, onions, and sulfur-rich foods
In SURMOUNT-4, participants who switched from tirzepatide to placebo regained more than 50% of their lost weight over 52 weeks
Docking analysis of compound 27 (Figure 5) within the active site of DPP-4 revealed potential binding interactions (102)
This was coupled with enhanced interactions at the top of TM1 and distinct and more sustained interactions within TM7 (Figure 6, Supplemental Table 3)