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For T1DM patients, insulin replacement is essential due to insufficient endogenous insulin secretion
In the latest JAMA Medical News podcast, Jennifer Abbasi interviews Rita Kalyani, MD, about investigational therapies including retatrutide, a triple agonist showing high efficacy for glycemic control and weight loss, and new oral options like orforglipron
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This gradual onset is similar to the timeline for other GLP-1 agonists to start working , though the triple receptor activation adds additional complexity to the process
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