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water for injection (WFI), sterile water solution, or bacteriostatic water for injection (BWFI) may be used

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Clinical trials have consistently demonstrated that this restoration leads to a dramatic, measurable reduction in specific biomarkers of systemic oxidative damage, such as TBARS (thiobarbituric acid reactive substances) and F2-isoprostanes, which are direct indicators of lipid membrane destruction

In September 2023, the FDA placed both on its Category 2 list of bulk substances that raise significant safety risks (FDA, 2023)