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For example, INS , islet amyloid polypeptide ( IAPP ), MAF bZIP transcription factor A ( MAFA ), pancreatic and duodenal homeobox 1 ( PDX1 ), and NK6 homeobox 1 ( NKX6.1 ), exhibited a varying degree of expression in cell subclusters, with the highest expression in -4 cells (Figure 3D)
Exploration of its downstream signaling pathway using integrative molecular and cellular approaches and evaluation of its clinical outcome will provide direct evidence to support potential clinical implication (summarized in Figure 1)
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