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Acute Toxicity Mice, intraperitoneal LD50: 750 mg/kg, with no other details provided besides the lethal dose
In contrast, Ex-4 is only found in the venom of the lizard Heloderma suspectum , with the endogenous GLP-1 being DDP-4 sensitive and 84% identical at the amino acids level to human GLP-1 14,15
In the connection between mitochondrial metabolism and aging, prior work reported decreased levels of LAC in subjects with Alzheimers disease (AD) as compared to cognitively healthy controls, with intermediate levels in subjects with subjective memory complaint or mild cognitive impairment [64]
Science 368 , eaaz7548 (2020)
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