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Month 3 After 12 weeks or 3 months, users experienced a 1.1% drop in HbA1c level, and fasting blood glucose levels dropped to 6.6 mmol/L from a baseline of 9.6 mmol/L

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Clinically, GLP-1RAs like semaglutide induce sweet hyposensitivity and reduce preference for hyperpalatable foods, an effect mediated by changes in endogenous GLP-1 secretion and synaptic plasticity in reward circuits (166)

PMID: 18075297

Primary benefits of retatrutide for non-diabetic weight loss include: Significant reduction in body weight Improved eating habits and control over cravings Increased energy for daily tasks and activities Enhanced self-confidence and mood Better participation in social activities involving food Smaller clothing sizes and improved mobility Lower risk of obesity-related complications A new option for patients who are refractory to other treatments