Oral hypoglycemic agents are prescribed for patients with type 2 diabetes mellitus or PCOS, to prevent ovarian hyperstimulation syndrome when undergoing ICSI or IVF, or to reduce weight gain while on antipsychotic medication (10)
Nevertheless, since GSH cannot be administered directlybecause of its insufficient absorption, stability and solubilityanalogues have been obtained, through modifications at the -glutamyl, cysteine and glycine moieties, and/or the functionalisation of the central cysteine, that are able to inhibit the activity of GSTs 69,87,105
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Rangos representativos en literatura: Modelos murinos DIO: 1, 3 o 10 nmol/kg semanal durante 4 a 12 semanas, con seguimiento de peso corporal, ingesta calrica y composicin corporal