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The heavy subunit (molecular weight about 73 kDa) exhibits the catalytic activity of the native enzyme and is also responsible for the feedback inhibition by GSH

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A separate 2024 meta-analysis in the journal Endocrine examining 29 trials with 26,985 participants with type 2 diabetes confirmed that semaglutide significantly reduced systolic blood pressure by about 2.31 mmHg compared to placebo or other antihyperglycemic agents

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