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Therapeutic targeting of ras/raf/mapk pathway by natural products: A systematic and mechanistic approach for neurodegeneration

Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome

1) Pro-angiogenic signaling (VEGFR2 Akt eNOS) In cell and animal models, BPC-157 increases VEGFR2 expression/internalization and activates downstream Akt-eNOS signaling, supporting endothelial tube formation and blood-flow recovery after ischemia

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The analyses included CAT and SOD enzymatic activities, quantification of total sulfhydryl groups, and measurement of ROS production using the DCF (2,7-dichlorofluorescein) assay