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CAFs-induced ECM remodeling results in increased tissue stiffness and the activation of mechanotransduction signaling pathways, such as integrin-FAK and YAP/TAZ signaling, thereby conferring increased malignancy to tumors (121)

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A variety of antioxidant supplements, including vitamins C, glutathione, selenium, and zinc, have been shown to improve sperm quality by reducing ROS levels and preventing oxidative damage (104, 105)