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Visible body composition changes from the combination usually become apparent at weeks 6-8, when AOD 9604 has been active for 2-4 weeks alongside escalating tirzepatide doses

nitrous oxide exposure can inactivate B12 Important: Do not take folic acid alone when B12 deficiency is possible or uncorrected, as this may worsen neurological damage Avoid measuring serum B12 immediately after injections due to falsely high results Dietary optimisation remains the preferred approach for those without absorption issues

Baseline matters

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Potential Benefits & Side Effects Observations from phase 2 and phase 3 clinical trials