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Higher body mass increases mechanical load across joints, accelerating cartilage wear with every step. Obesity contributes to systemic inflammation and metabolic dysfunction that can directly affect joint tissues, even in non-weight-bearing joints, he added

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Together with findings from SELECT [18], these data suggest that GLP-1-based therapies may exert renoprotective effects that are not contingent on glycemic modulation, expanding their potential relevance across metabolic phenotypes