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All other authors declare no competing interests

Confocal imaging of wildtype vs TMEM55B KO cells stained for endogenous LAMP2 to mark lysosomes, paired with automated image analysis by OrgaMapper 39 revealed the accumulation of lysosomes in the cell periphery in TMEM55B KO cells, in agreement with previous work using siRNA 11,31 (Fig

Lastly another stage is assumed and a growth takes place which is for the most part unpigmented and which in its tendency to break down and ulcerate, reveals its malignant nature. 2 Today we would see this as a classic description of the transformation from in-situ disease to invasive and then the formation of an amelanotic nodule of more deeply invasive melanoma