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Severe deficiency : Weekly or biweekly injections may initially be required to correct anemia and neurological symptoms

In the context of sepsis, experimental studies have demonstrated that adiponectin deficiency exacerbates inflammation, promotes leukocytes and platelet adhesion, and compromises bloodbrain barrier integrity, partly through the upregulation of E-selectin

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Its prevalence is increasing worldwide, and, like obesity, it affects progressively younger populations compared to the past, with potentially greater impact on chronic complications