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The predicted binding mode places neuromedin C along the canonical peptide-binding groove, consistent with the class B1 GPCR two-domain recognition paradigm in which peptide ligands are initially oriented by extracellular receptor elements and subsequently stabilize the active TM architecture required for signaling (Figure 4)

Bibcode:2017PNAS..114E1196C

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However, the volume of the nucleus does not change significantly, there is a lack of chromatin condensation but the chromosome structure does not disappear, and the rupture of the cell membrane does not occur in the process of ferroptosis

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