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As an adhesion molecule, CD11a can facilitate the recruitment and entry of T cells into the synovial tissue via LFA-1(CD11a/CD18)/intercellular cell adhesion molecule (ICAM)-1 pathway (139)
It can reverse the pathological expression of a substantial percentage of genes in metastasis-prone colon cancer, indicating its potential to alter the course of cancer development
Potential concerns include effects on angiogenesis that theoretically could influence tumor development or progression, though preclinical studies show context-dependent effects that inhibit pathological angiogenesis in some tumor models
Acta Anat (Basel) 116:6973 Kroeze Y, Oti M, van Beusekom E, Cooijmans RHM, van Bokhoven H, Kolk SM, Homberg JR, Zhou H (2018) Transcriptome analysis identifies multifaceted regulatory mechanisms dictating a genetic switch from neuronal network establishment to maintenance during postnatal prefrontal cortex development
Regular and excessive alcohol consumption can significantly impair NAD+ synthesis
