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doi:10.1007/s12603-013-0023-x Saruhan E, Sertoglu E, Unal Y, Bek S, Kutlu G

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

Folate supplementation without adequate B12 can also partially mask B12-related anaemia in routine blood tests, making deficiency harder to detect through a standard CBC alone (Cikot et al., 2001, British Journal of Nutrition)

Even those who eventually tolerate high concentrations well typically experience problems when starting there