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The apoplastic oxidative burst in response to biotic stress in plants: a tree component system
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2 Transporter-Mediated DDIs Efflux transporters (P-gp, BCRP) Uptake transporters (OATP, OCT) Example: P-gp inhibition increasing digoxin exposure
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monitoring advised Renal Considerations: use with caution in patients with impaired kidney function Heart Rate: mild increase possible due to glucagon receptor activity Pharmacokinetics Half-Life: approximately 67 days Dosing Interval: supports once-weekly administration Metabolism: degraded via proteolytic pathways
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