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Ultimately, the compounding effect of NO and oxidative damage within the mitochondria can spiral into a vicious cycle, where increasing respiratory inhibition produces more free radicals, which further increases respiratory inhibition and induces cell death (Poderoso et al., 2019

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Anyone can become dehydrated, but the risk is higher if you: Work outdoors in the heat Exercise regularly Spend long days on the golf course Coach or play outdoor sports Work in construction, landscaping, or farming Travel frequently Have vomiting or diarrhea Drink alcohol Take certain medications, including some diuretics Even spending a day at the lake can leave you more dehydrated than you realize

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