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When empirical measures of parameter uncertainty (e.g., standard errors or confidence intervals) were not available from published sources, a conservative range of 25% was applied around the base-case value

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This can pose risks to consumers, as the safety and efficacy of these products are not guaranteed

According to ICH Q2(R1) guidelines, the accuracy studies were performed using three levels of concentrations, i.e., 80%, 100% and 120%, by replicate analysis ( n = 3)

Semaglutide requires gradual dose escalation over 45 months to minimize gastrointestinal side effects like nausea, which affects approximately 44% of patients