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The researchers caution that patients should not expect GLP-1 drugs to become arthritis treatments anytime soon
GLP-1 therapies can be valuable tools, but they are not stand-alone solutions
Senolytic compounds may help eliminate these cells before they become a problem
The theory is that continuous high-dose GLP-1 agonist exposure can lead to partial receptor desensitization, and a brief period at a lower dose allows the receptors to upregulate
At screening, the mean duration of diabetes was approximately 12 years, the mean BMI was approximately 31 kg/m2, mean eGFR was 80.6 mL/min/1.73 m2 and 86.1% of patients had an eGFR 60 mL/min
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