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doi: 10.1056/NEJMoa1406656 80 DarsaliaVKleinTNystrmTPatroneC

Given the early stages of this therapeutic approach senescence therapeutics will need to overcome challenges related to biomarker identification, target engagement, CNS penetrance and safety

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Common symptoms that may indicate conditions associated with low DHEA-S: Persistent fatigue: Overwhelming tiredness can be due to decreased hormone support for energy metabolism Decreased muscle mass: Reduced strength and muscle tone can result from diminished anabolic support Mood changes: Depression, anxiety, or reduced sense of well-being may result from altered neurosteroid effects in the brain Cognitive difficulties: Problems with memory or concentration can be related to DHEA's role in brain function Reduced libido: Decreased sexual interest may be due to lower testosterone and estrogen production Joint pain: Discomfort in joints, possibly related to reduced anti-inflammatory effects Bone density loss: Gradual weakening of bones can result from decreased hormonal support for bone mineralization Common symptoms that may indicate conditions associated with high DHEA-S in women: Hirsutism: Excessive hair growth in male-pattern locations (face, chest, abdomen) can be due to increased androgen effects Acne: Skin breakouts from increased sebum production may be stimulated by androgens Menstrual irregularities: Infrequent or absent periods can result from a hormonal imbalance affecting ovulation Male-pattern hair loss: Thinning at the crown or temples can result from androgenic effects on hair follicles Insulin resistance: Difficulty processing glucose effectively, potentially leading to weight gain Mood swings: Irritability or aggression can result from fluctuating hormone levels In men, high DHEA-S typically causes fewer noticeable symptoms but may be associated with conditions requiring medical attention