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STEP and SURMOUNT randomized controlled trials of semaglutide and tirzepatide have reported clinically significant weight reduction across treatment arms

Stress and lack of sleep can increase NPY production, leading to overeating

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If you experience persistent nausea or appetite changes, documenting injection time, meal size, and symptom onset helps your provider distinguish between medication tolerance and timing-related triggers, enabling more targeted adjustments

Last reviewed: May 20, 2026 Last updated: May 20, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations