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While the gastrointestinal effects (nausea, diarrhea, vomiting) are similar to other GLP-1 medications like Wegovy and Mounjaro, retatrutide has one unique finding: dysesthesia (abnormal touch sensations) in 20.9% of patients at the 12mg dose in TRIUMPH-4, and 12.5% at 12mg in the larger TRIUMPH-1 trial

Seeing GLP-1 present in the joint environment opens up the possibility that its role extends beyond metabolic pathways into local inflammatory modulation

Appetite usually increases, and the feeling of fullness after meals may decrease

Your provider should discuss storage conditions specific to your prescribed compound