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Genetic analysis revealed downregulation of genes associated with lipid synthesis, such as FAS and SCD1, in the liver
National Key R&D Program of China (2022YFA1104500)
Urinary excretion of trace elements in humans after sodium 2,3-dimercaptopropane-1-sulfonate challenge test
The reviewer GM declared a shared affiliation, with no collaboration, with the authors to the handling editor at the time of the review
Men using TRT lost approximately 11 pounds of fat while gaining 9 pounds of lean mass over 18 months in controlled studies Long-term testosterone therapy produced average weight loss of 36 pounds without dietary intervention in one registry study Meta-analysis of 10 RCTs showed TRT reduced BMI by 0.57 kg/m2 and waist circumference by 2.78 cm in obese men Lean body mass increased by an average of 1.96 kg with TRT in meta-analysis findings Combined GLP-1 and lifestyle intervention reduced lean tissue loss to single-digit percentages of total weight lost Registry studies tracking long-term testosterone therapy outcomes provide particularly valuable data
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