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Among emerging anti-diabetic candidates, glucagon like peptide-1 (GLP-1) based therapies carry special cardiovascular implications (Figure 1)
Some DSIP claims are based on its proposed interaction with the HPA axis, the bodys main stress-response system that regulates hormones such as cortisol
In animal models, GLP-1/GLP-1R signalling has demonstrated to be involved in key macrophage functions such as phagocytosis and migration, though further research is needed to confirm these effects in humans (45)
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