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To integrate possible mechanistic events, a unified proposal for the role of cuproptosis in Wilson disease is suggested: (1) Published data support that copper ions induce oxidative stress by generating ROS, including hydroxyl radicals and H 2 O 2 , via the Haber-Weiss and Fenton reactions [21,27,45-49,59,77,90-92]
doi: 10.1186/s12987-020-00230-3 40
ROS causes GSTs-JNK-c-Jun complex formation blocking JNK signaling pathway and preventing the events associated with this signaling cascade
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