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Relative contraindications may include significant cancer risk factors, bleeding disorders, and concurrent use of anticoagulant medications

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To ensure statistical comparability across studies, transformations followed the methods recommended in the Cochrane Handbook for Systematic Reviews of Interventions (e.g., converting medians and inter-quartile ranges to means and standard deviations)

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Substance use as a risk factor for bipolar disorder: a systematic review

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All authors reviewed the manuscript

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